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Using two separate drugs to lose weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight loss and the people that go through it one should err assisting caution and allow the FDA do its job and demand some investigation be done in order that the public understands the side effects and dangers of the medications before we take them. Keep in mind that drug companies are in business to generate money and that they would say anything to keep people on their own medications. Researchers found that participants taking this drug for a year, dropped excess weight within 4 weeks and have kept the load off throughout the 56 weeks with the study. Contrave is often a combination in the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which are made up of more than one active ingredient, which can make them far better and safer. Combo-pilling is the newest fad or also the newest into the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is now popular is the fact that as of right now there are not any long term prescription slimming capsules that have been approved by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and must not be taken in those with seizure disorders. The drug may also raise blood pressure level and heartrate, and mustn't be used in individuals with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must stop used in patients with uncontrolled high blood pressure level, as well as by a person with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients with a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients for the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking. "There were no warning signs of depression or suicidal thoughts in trial participants," said Fujioka.